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养精胶囊对老年SD大鼠性功能的影响
目的 观察养精胶囊对老年雄性SD大鼠性功能的影响,并探讨其可能的影响机制.方法 将40只老年雄性SD大鼠随机分为实验组和对照组,实验组给予养精胶囊(0.5g/kg·d-1)灌胃4周,对照组给予等剂量生理盐水灌胃相同时间.4周后通过观察两组大鼠阴茎勃起变化、检测血清睾酮水平和免疫组化方法检测大鼠阴茎海绵体组织中内皮型一氧化氮合酶(eNOS)及海绵体组织血管中CD34分子表达的变化情况等评价大鼠性功能变化情况.结果 (1)对照组老年大鼠干预后血清总睾酮水平较干预前下降,但组间比较差异无统计学意义(P>0.05);养精胶囊组老年大鼠干预后血清总睾酮水平较干预前有所提高,但差异亦无统计学意义(P>0.05);(2)在老年大鼠性功能指标方面:养精胶囊干预组老年大鼠阴茎勃起次数、勃起潜伏期及勃起维持时间均较对照组有所改善.(3)阴茎海绵体组织HE染色结果提示:养精胶囊组老年大鼠阴茎海绵体组织血管管腔明显扩张,充血,管腔内壁变薄;对照组老年大鼠阴茎海绵体组织内,血管管腔未见明显充盈扩张,管腔内充血不明显,且管腔有大量残留的陈旧性血液.(4)免疫组化结果提示:两组大鼠海绵体组织中,均可见深染的棕褐色阳性颗粒,但深染程度和颗粒分布密度不一.低倍镜(*100)视野下观察,药物干预后实验组大鼠阴茎海绵体组织中eNOS的阳性颗粒的数量明显高于对照组(P<0.05);(5)微血管密度结果提示:实验组老年大鼠阴茎海绵体组织血管内皮中CD34的表达明显强于对照组,高倍镜下(*400)观察,实验组微血管密度MVD值较对照组升高(P<0.05).结论 养精胶囊能促进血清睾酮的分泌,增强阴茎海绵体组织内eNOS的表达,这可能是养精胶囊改善大鼠性功能和阴茎勃起的作用机制.高永金,金保方,张新东,薛宇阳,夏国守,孙大林 - 中国男科学杂志文章来源： 万方数据 -
Steering control of a capsule robot in curve environment by magnetic navigation is not yet solved completely.A petal-shaped capsule robot with less steering resistance based on multiple wedge effects is presented,and an optimization method with two processes for determining the orientation of a pre-applied universal magnetic spin vector is proposed.To realize quick and non-contact steering swimming,a fuzzy comprehensive evaluation method for optimizing the steering driving angle is presented based on two evaluation indexes including the average steering speed and the average steering trajectory deviation,achieving the initial optimal orientation of a universal magnetic spin vector.To further reduce robotic magnetic vibration,a main target method for optimizing its final orientation,which is used for fine adjustment,is employed under the constrains of the magnetic moments.Swimming experimental results in curve pipe verified the effectiveness of the optimization method,which can be effectively used to realize non-contact steering swimming of the petal-shaped robot and reduce its vibration.- 中国机械工程学报文章来源： 万方数据
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