科创中国

In design of flexure mechanism, diminishing the parasitic-motion is a key point to improve the accuracy. However, most of existing topics concentrate on improving the accuracy of linear-motion flexure mechanisms via compensating the parasitic error, but few research the multi-dimensional flexure mechanisms. A general design principle and method for high-precision flexure mechanisms based on the parasitic-motion compensation is presented, and the proposed method can compensate the parasitic rotation in company with translation, or the parasitic translation in company with rotation, or both. The crucial step for the method is that the parasitic motion of a flexure mechanism is formulated and evaluated in terms of its compliance. The overall compliance matrix of a general flexure mechanism is formulated by using screw theory firstly, then the criteria for the parasitic motions is introduced by analyzing the characteristics of the resultant compliance matrix as well as with aid of the concept of instantaneous rotation center. Subsequently, a compliance-based compensation approach for reducing parasitic-motion is addressed as the most important part. The design principles and procedure are further discussed to help with improving the accuracy of flexure mechanisms, and case studies are provided to illustrate this method. Finally, an analytical verification is provided to demonstrate that the symmetry design philosophy widely used in flexure design can effectively improve accuracy in terms of the proposed method. The proposed compensation method can be well used to diminish the parasitic-motion of multi-dimensional flexure mechanisms.

The compliance modeling and rigidity performance evaluation for the lower mobility parallel manipulators are still to be remained as two overwhelming challenges in the stage of conceptual design due to their geometric complexities. By using the screw theory, this paper explores the compliance modeling and eigencompliance evaluation of a newly patented 1T2R spindle head whose topological architecture is a 3-RPS parallel mechanism. The kinematic definitions and inverse position analysis are briefly addressed in the first place to provide necessary information for compliance modeling. By considering the 3-RPS parallel kinematic machine(PKM) as a typical compliant parallel device, whose three limb assemblages have bending, extending and torsional deflections, an analytical compliance model for the spindle head is established with screw theory and the analytical stiffness matrix of the platform is formulated. Based on the eigenscrew decomposition, the eigencompliance and corresponding eigenscrews are analyzed and the platform's compliance properties are physically interpreted as the suspension of six screw springs. The distributions of stiffness constants of the six screw springs throughout the workspace are predicted in a quick manner with a piece-by-piece calculation algorithm. The numerical simulation reveals a strong dependency of platform's compliance on its configuration in that they are axially symmetric due to structural features. At the last stage, the effects of some design variables such as structural, configurational and dimensional parameters on system rigidity characteristics are investigated with the purpose of providing useful information for the structural design and performance improvement of the PKM. Compared with previous efforts in compliance analysis of PKMs, the present methodology is more intuitive and universal thus can be easily applied to evaluate the overall rigidity performance of other PKMs with high efficiency.

The existing researches on singularity of parallel mechanism are mostly limited to the property and regularity of singularity locus and there is no further research into the geometric relationship between uncontrolled kinematic screw and parallel mechanism in singularity.A 3UPS-S parallel mechanism is presented which fulfils 3-DOF in rotation.The regularity of nutation angle singularity is analyzed based on the Jacobian matrix,and the singularity surface of 3UPS-S parallel mechanisms is obtained.By applying the concept of reciprocal product in screw theory,the singular kinematic screw is derived when 3UPS-S parallel mechanism is in singularity.The geometric relationship between singular kinematic screw and singular configuration of 3UPS-S parallel mechanism is investigated by using programs in MATLAB.It is revealed that there are two kinds of situation.Firstly,the three limbs of 3UPS-S parallel mechanism intersect the singular kinematic screw in space simultaneously;Secondly,two limbs cross the singular kinematic screw while the third limb parallels with that screw.It is concluded that the nutation angle singularity of 3UPS-S parallel mechanism belongs to the singular linear complexes.This paper sheds light into and clarifies the geometric relationship between singular kinematic screw and singular configuration of 3UPS-S parallel mechanism.

Parallel robots with SCARA(selective compliance assembly robot arm) motions are utilized widely in the field of high speed pick-and-place manipulation. Error modeling for these robots generally simplifies the parallelogram structures included by the robots as a link. As the established error model fails to reflect the error feature of the parallelogram structures, the effect of accuracy design and kinematic calibration based on the error model come to be undermined. An error modeling methodology is proposed to establish an error model of parallel robots with parallelogram structures. The error model can embody the geometric errors of all joints, including the joints of parallelogram structures. Thus it can contain more exhaustively the factors that reduce the accuracy of the robot. Based on the error model and some sensitivity indices defined in the sense of statistics, sensitivity analysis is carried out. Accordingly, some atlases are depicted to express each geometric error's influence on the moving platform's pose errors. From these atlases, the geometric errors that have greater impact on the accuracy of the moving platform are identified, and some sensitive areas where the pose errors of the moving platform are extremely sensitive to the geometric errors are also figured out. By taking into account the error factors which are generally neglected in all existing modeling methods, the proposed modeling method can thoroughly disclose the process of error transmission and enhance the efficacy of accuracy design and calibration.

In the prediction of active vibration isolation performance,control force requirements were ignored in previous work.This may limit the realization of theoretically predicted isolation performance if control force of large magnitude cannot be supplied by actuators.The behavior of a feed-forward active isolation system subjected to actuator output constraints is investigated.Distributed parameter models are developed to analyze the system response,and to produce a transfer matrix for the design of an integrated passive-active isolation system.Cost functions comprising a combination of the vibration transmission energy and the sum of the squared control forces are proposed.The example system considered is a rigid body connected to a simply supported plate via two passive-active isolation mounts.Vertical and transverse forces as well as a rotational moment are applied at the rigid body,and resonances excited in elastic mounts and the supporting plate are analyzed.The overall isolation performance is evaluated by numerical simulation.The simulation results are then compared with those obtained using unconstrained control strategies.In addition,the effects of waves in elastic mounts are analyzed.It is shown that the control strategies which rely on unconstrained actuator outputs may give substantial power transmission reductions over a wide frequency range,but also require large control force amplitudes to control excited vibration modes of the system.Expected power transmission reductions for modified control strategies that incorporate constrained actuator outputs are considerably less than typical reductions with unconstrained actuator outputs.In the frequency range in which rigid body modes are present,the control strategies can only achieve 5–10 dB power transmission reduction,when control forces are constrained to be the same order of the magnitude as the primary vertical force.The resonances of the elastic mounts result in a notable increase of power transmission in high frequency range and cannot be attenuated by active control.The investigation provides a guideline for design and evaluation of active vibration isolation systems.

在介绍物流企业及其文化竞争力建设的基础上,运用模糊矩阵分析法构建物流企业文化竞争力的评价指标体系,探讨我国物流企业文化竞争力建设的主要措施,以期为我国物流企业文化竞争力建设提供一定参考.

背景:Notch信号通路在多种人类恶性肿瘤的发生、发展中起关键作用.研究显示Notch与NF-κB信号通路之间的交互作用可促进胰腺癌进展.目的:明确Notch信号通路对胰腺癌侵袭性的影响及其可能机制.方法:体外培养人胰腺癌细胞株BxPC3,以Notch-1 siRNA下调其Notch-1表达,同时设置转染对照siRNA的阴性对照组和不予siRNA干扰的空白对照组.以Transwell细胞侵袭实验观察各组BxPC3细胞的侵袭能力,电泳迁移率变动分析(EMSA)检测NF-κB活性,蛋白质印迹法检测Notch-1、NF-κB p65、血管内皮生长因子(VEGF)、基质金属蛋白酶-9(MMP-9)蛋白表达.结果:经Notch-1 siRNA干扰、Notch-1表达下调的BxPC3细胞,Transwell细胞侵袭实验穿膜细胞数较空白对照组和阴性对照组显著减少(26.5±1.3对78.5±2.4和76.7 ±2.2,P<0.01),NF-κB活性显著降低(P<0.01),NF-κB p65、VEGF、MMP-9蛋白表达显著下调(P<0.05).结论:Notch-1可通过激活NF-κB促进其下游基因VEGF、MMP-9表达,由此增强胰腺癌的侵袭性.