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左氧氟沙星铜(II)配合物的合成及生物活性研究
合成了四个新左氧氟沙星铜(II)配合物:[Cu(Lvfx)(Bipy)(H2O)]Cl·4H2O(1),[Cu(Lvfx)(Phen)(H2O)]Cl·5H2O(2),[Cu(Lvfx)(Tatp)(H2O)]Cl·5H2O(3),[Cu(Lvfx)(Dppz)(H2O)]Cl·4.5H2O(4){Lvfx=左氧氟沙星,Bipy:2,2'-联吡啶,Phen=1,10-邻菲罗啉,Tatp=1,4,8,9-四氮三联苯,Dppz=二吡啶并[3,2-a:2',3'-c]吩嗪},并通过红外光谱法、紫外-可见光谱法、元素分析、原子吸收光谱法、摩尔电导率分析和差热.热重分析对配合物进行了表征.用滤纸片扩散法和试管二倍稀释法分别测试了配合物及配体对大肠杆菌、金黄色葡萄球菌的抗菌活性,结果显示配合物(3)对大肠杆菌具有最佳的抑菌效果.采用荧光光谱法初步研究了配合物与BSA的相互作用.结果表明,四个配合物均对BSA的荧光有较强的猝灭作用,且发生了能量转移,其与BSA的结合常数(K)分别为4.7*103、5.7*103、5.0*103和1.7*103L·mol-1,结合位点n分别为0.59、0.83、0.81和0.69.邓素文,胡伟,林若琳,钟美,陈冬贵,熊亚红,刘小平 - 化学研究与应用文章来源： 万方数据 -
The existing researches on singularity of parallel mechanism are mostly limited to the property and regularity of singularity locus and there is no further research into the geometric relationship between uncontrolled kinematic screw and parallel mechanism in singularity.A 3UPS-S parallel mechanism is presented which fulfils 3-DOF in rotation.The regularity of nutation angle singularity is analyzed based on the Jacobian matrix,and the singularity surface of 3UPS-S parallel mechanisms is obtained.By applying the concept of reciprocal product in screw theory,the singular kinematic screw is derived when 3UPS-S parallel mechanism is in singularity.The geometric relationship between singular kinematic screw and singular configuration of 3UPS-S parallel mechanism is investigated by using programs in MATLAB.It is revealed that there are two kinds of situation.Firstly,the three limbs of 3UPS-S parallel mechanism intersect the singular kinematic screw in space simultaneously;Secondly,two limbs cross the singular kinematic screw while the third limb parallels with that screw.It is concluded that the nutation angle singularity of 3UPS-S parallel mechanism belongs to the singular linear complexes.This paper sheds light into and clarifies the geometric relationship between singular kinematic screw and singular configuration of 3UPS-S parallel mechanism.- 中国机械工程学报文章来源： 万方数据
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