科创中国

The idle time which is part of the order fulfillment time is decided by the number of items in the zone; therefore the item assignment method affects the picking efficiency. Whereas previous studies only focus on the balance of number of kinds of items between different zones but not the number of items and the idle time in each zone. In this paper, an idle factor is proposed to measure the idle time exactly. The idle factor is proven to obey the same vary trend with the idle time, so the object of this problem can be simplified from minimizing idle time to minimizing idle factor. Based on this, the model of item assignment problem in synchronized zone automated order picking system is built. The model is a form of relaxation of parallel machine scheduling problem which had been proven to be NP-complete. To solve the model, a taboo search algorithm is proposed. The main idea of the algorithm is minimizing the greatest idle factor of zones with the 2-exchange algorithm. Finally, the simulation which applies the data collected from a tobacco distribution center is conducted to evaluate the performance of the algorithm. The result verifies the model and shows the algorithm can do a steady work to reduce idle time and the idle time can be reduced by 45.63% on average. This research proposed an approach to measure the idle time in synchronized zone automated order picking system. The approach can improve the picking efficiency significantly and can be seen as theoretical basis when optimizing the synchronized automated order picking systems.

As the popularization of dual ring fieldbus,the optimized dual ring synchronization methods are still in short.The current synchronization methods are generally established in traditional industrial fieldbus,in which transmission is commonly considered in single track,the two-way transmitting cannot take full effect,and would result in unwanted idle load on equipment lines.In stamp-transferring part,the synchronizing algorithm is not properly processed to diminish the latency,so the real-time performance of entire system cannot be ensured.To support the synchronization control of stations in the CNC system,a real-time time synchronization method for dual ring fieldbus in the CNC system is designed in this paper.In this method a synchronizing message transmission scheme based on dual ring architecture and the synchronization algorithm between master and secondary stations are integrated.In the scheme,the clock models of both master and secondary stations are optimized with corresponding modules and the stamp data transmission based on the dual ring fieldbus is devised exclusively,so the transmitting efficiency improves with less idle work.In the algorithm,all the secondary stations can accomplish the consistent state with master station by updating clock discrepancy information in one communication cycle,and it takes the advantage of two-way transmitting and makes the best use of dual ring structure,so the real-time performance of the system can be promoted while retaining the precision of synchronization.To evaluate the performance,the costs of the method and errors during synchronizing are noted and analyzed based on the actual running environment in the industrial fieldbus.The results show that it reduces communication cost and ensures the smoothness of the system with low lag effects under heavy load.The proposed time synchronization method optimizes the architecture of sync message transmission in dual ring fieldbus,and improves the efficiency of time synchronization in the stations of CNC system.

The current research of real-time observation for vehicle roll steer angle and compliance steer angle(both of them comprehensively referred as the additional steer angle in this paper) mainly employs the linear vehicle dynamic model, in which only the lateral acceleration of vehicle body is considered. The observation accuracy resorting to this method cannot meet the requirements of vehicle real-time stability control, especially under extreme driving conditions. The paper explores the solution resorting to experimental method. Firstly, a multi-body dynamic model of a passenger car is built based on the ADAMS/Car software, whose dynamic accuracy is verified by the same vehicle's roadway test data of steady static circular test. Based on this simulation platform, several influencing factors of additional steer angle under different driving conditions are quantitatively analyzed. Then ε-SVR algorithm is employed to build the additional steer angle prediction model, whose input vectors mainly include the sensor information of standard electronic stability control system(ESC). The method of typical slalom tests and FMVSS 126 tests are adopted to make simulation, train model and test model's generalization performance. The test result shows that the influence of lateral acceleration on additional steer angle is maximal(the magnitude up to 1°), followed by the longitudinal acceleration-deceleration and the road wave amplitude(the magnitude up to 0.3°). Moreover, both the prediction accuracy and the calculation real-time of the model can meet the control requirements of ESC. This research expands the accurate observation methods of the additional steer angle under extreme driving conditions.

The methods of improving the dynamic performance of high speed on/off solenoid valve include increasing the magnetic force of armature and the slew rate of coil current, decreasing the mass and stroke of moving parts. The increase of magnetic force usually leads to the decrease of current slew rate, which could increase the delay time of the dynamic response of solenoid valve. Using a high voltage to drive coil can solve this contradiction, but a high driving voltage can also lead to more cost and a decrease of safety and reliability. In this paper, a new scheme of parallel coils is investigated, in which the single coil of solenoid is replaced by parallel coils with same ampere turns. Based on the mathematic model of high speed solenoid valve, the theoretical formula for the delay time of solenoid valve is deduced. Both the theoretical analysis and the dynamic simulation show that the effect of dividing a single coil into N parallel sub-coils is close to that of driving the single coil with N times of the original driving voltage as far as the delay time of solenoid valve is concerned. A specific test bench is designed to measure the dynamic performance of high speed on/off solenoid valve. The experimental results also prove that both the delay time and switching time of the solenoid valves can be decreased greatly by adopting the parallel coil scheme. This research presents a simple and practical method to improve the dynamic performance of high speed on/off solenoid valve.

明末清初理学家孙奇逢,面对家国式微、异族入主的困境,遥契孔子通权达变妙境,老而作《易》,求解于天道而终落于人道.他深味易之天人贯通之意涵与现实人生"时遇"之重要,在整体天下意识之下,形成其基于心性学视野下的易学思想.其学说以心性本体论为哲学根基,以从道趋时、进德修业之人生关怀为着落,是对《周易》"时"的哲学的继承与发展.

Objective To detect the cell viability and the expressions of stem cell surface markers after chemotherapeutic drug treatment.Methods We observed the cytotoxic effects of three chemotherapeutic agents[epirubicin(Epi),fluorouracil(5-FU)and cyclophosphamide(Cyc)]in three cell lines,and the cell viabilities after removed these chemotherapeutic agents.Expressions of stem cell surface markers CD44,CD24,CD90,CD14 and aldehyde dehydrogenase1(ALDH1)in breast cancer cells were analyzed by real-time PCR.The post hoc analysis(Tukey's tests)in conjunction with one-way ANOVA was used for statistical analysis.Results The initial cytotoxic efficacy was most notable.After the treatment of the same therapeutic agents,cell viability was decreased by 64.8%35.14%,32.25%in BT-483 cells,66.4%,22.94%and 45.88%in MDA-MB-231 cells,97.1%,99.5%and 76.4%in MCF cells.The difference was significant compared with that before treatment(P=0.000).However,the inhibitory effects were diminished after chemotherapeutic agent withdrawal.Cell viabilities were increased to 167.9%,212.04%and 188.66%in MDA-MB-231 cells at48 h after withdrawal.At 72 h after withdrawal,cell viability was increased with a significant difference in three cell lines(all P values=0.000).Expressions of CD44 and ALDH1 were most prevalent for MDA-MB-231,BT-483 and MCF-7 cells.ALDH1 mRNA level was significant higher in BT-483(HER-2 overexpression cell line)than MDA-MB-231(triple negative cell line)(P=0.012).CD14 mRNA level in MCF-7 cells were significantly lower than that in MDA-MB-231 and BT-483(P=0.003,0.001).BT-483 showed significantly higher level of CD44 than MDA-MB-231 and MCF-7 cell line(P=0.013,0.020),and no significant difference was detected between MDA-MB-231 and MCF-7 breast cancer cells(P=0.955).CD90 mRNA expressions were detected in MDA-MB-231 cells and MCF-7 cells,but not in BT-483 cells.Conclusion Some malignant cells could survive in vitro and begin to proliferate again between cycles of chemotherapy.

针对当前基于自然特征的增强现实效率低,提出一种新的基于ORB自然特征的实时注册方法.提取视频帧与基准图像中的ORB特征点,使用汉明距离匹配,利用RANSAC算法筛选得到最佳匹配点对,确定摄像机的位姿.将三维虚拟物体叠加到真实场景中,达到虚实结合的效果.实验表明,在不同尺度角度、一定环境光变化、复杂背景和基准图像部分遮挡的情况下,该AR系统都具有良好的性能,跟踪定位准确度高,速度基本达到实时要求

根据化学事故应急救援与处置现场环境污染快速、实时检测需要,提出了一种化学污染物微流控芯片实时检测系统的设计方案,进行了系统的总体设计和细化设计,论述了系统设计涉及的复杂基质样品微流控芯片预处理技术,特别是固相萃取样品预处理技术、快速灵敏的微流控芯片检测技术、微流控芯片的模拟仿真、设计、集成与控制技术,以及便携式微流控芯片分析仪器的硬件设计和软件开发技术等关键技术及其研究方法,探讨了微流控芯片分离与检测单元的设计与实验、复杂基质样品的微流控芯片预处理单元设计与实验、原理性样机的研制与实验、微流控分析检测方法库和数据库的建立等系统设计的主要研究工作内容及其技术途径.通过微流控芯片分析检测系统包括样品预处理、混合、分离等单元,检测器单元,控制系统和信息处理单元的科学设计,可构建高度集成化、便携化、微型化的微流控分析检测系统,使系统具有适合小分子化合物等环境污染物的分析检测架构.