科创中国

为实现白车身装配特征位置参数的在线检测,监控和保障白车身焊接尺寸质量,研制了一种基于线激光摆动扫略的白车身装配特征机器人在线检测系统.提出了摆动式线激光单目视觉传感器的测量系统方案和传感器参数标定方法及传感器摆动运动标定方法;分析了传感器摆动采集光刀图像的特点,进而提出了面向孔槽、柱状类装配特征的光刀点云提取算法及位置参数计算方法;进行了系统集成,开发了在线检测系统,并展开工程应用验证.验证结果表明:本技术实现了对白车身各类装配特征快速、精密、稳定的检测.

Models of optimal escape strategy predict that animals should move away when the costs of fleeing (metabolic and opportunity costs) are outweighed by the costs of remaining. These theoretical models predict that more vulnerable individuals should be more reactive, moving away when an approaching threat is further away. We tested whether escape behaviour (includ- ing 'escape calling') ofLithobates sphenocephalus approached by a human was influenced by body size or the initial microhabi- tat that the individual was found in. Irrespective of their size, frogs in the open tended to remain immobile, enhancing their cryp- sis. Frogs in cover showed different responses according to their body size, but, contrary to our initial predictions, larger frogs showed greater responsiveness (longer flight initiation distance and distances fled) than small frogs. Small frogs tended to remain closer to water and escaped into water, while larger individuals were more likely to jump to terrestrial cover and call during escape. Density of frogs near the focal animal had no effect on escape behaviour. This study indicates a range of escape responses in this species and points to the importance of divergent escape choices for organisms which live on the edge of different environments .

Life-history theory predicts that in hibemators age of maturation is related positively to body size and negatively to the duration of active season aboveground. Yellow souslik is a large-sized ground squirrel with long hibernation, which suggests late maturation. We used four-year field observations of marked individuals to determine the age of maturation in males through analysis of age-dependent variation in body size, mass, androgen status, timing of spring emergence, ranging patterns and social behavior during the mating season. Yearling males were smaller, lighter, had lower level of fecal testosterone, emerged later and had smaller home ranges than older males. Social activity and the number of females encountered did not differ between age classes. After the second hibernation none of the studied parameters varied with age. Cluster analysis revealed two behavioral tactics: "active" males (adults only) emerged earlier, ranged more widely, initiated more contacts, encountered more females and were heavier than "passive" males (both yearling and adult). Thus, males of S. fulvus reached adult size and matured after two hibernations, which is relatively fast for such a big species with short active period. Indirect evidence for copulations and high variation among yearlings in all parameters suggest that some of them might successfully compete with adults. Active tactic of wandering and searching for females is energetically costly, and probably only adult males in good physical condition can afford it, whereas passive tactic of residing is energy saving and good for adults in poor condition and for yearlings that are continuing to grow.

本文研究了冷藏后的大久保桃适宜的催熟方式、温度和时间对桃果实和软白桃罐头感官品质和理化指标的影响,并分析了原料利用率.结果表明:大久保桃采用打孔的PE袋包装,催熟效果较好,此时桃的腐败指数和褐变指数低,风味浓郁;有效冷藏18d内的大久保桃,30℃催熟3d后,生产的软白桃罐头感官和理化指标均达到国标要求;原料利用率均保持在83.31%以上.该研究为软白桃罐头加工中的桃催熟处理提供了技术依据.

应用溶剂提取法、萃取法和柱色谱技术对禹白附的化学成分进行提取分离.根据波谱数据(1HNMR、13CNMR、MS、IR)和理化性质鉴定了2个化合物的结构,分别为对乙酰氨基酚(1)、β-谷甾醇(2).化合物1为首次从该植物中获得,本研究为进一步开发利用禹白附提供了科学依据.

目的:评价白消安(Bu)的血药浓度与造血干细胞移植临床效果的相关性.方法:22例移植患者预处理采用静脉剂型Bu,观察疗效及相关毒性.采用2007年文献报道的柱前衍生高效液相色谱法对Bu给药前和给药后不同时间的血药浓度进行监测,计算Bu药-时曲线下面积(AUC).结果:胃肠道反应、肝毒性、口腔黏膜炎和移植物抗宿主病与Bu的AUC值正相关.AUC0~6h在900~1400μmol.min.L-1之间时,移植患者的死亡风险下降,过高或过低的AUC值增加死亡风险.结论:根据Bu血药浓度监测及时调整药物剂量,有助于造血干细胞移植患者的临床预测和减少术后并发症.

目的:建立肝毒净丸的质量标准.方法:采用TLC鉴别虎杖、厚朴、片姜黄,采用HPLC测定虎杖中白藜芦醇苷的含量.结果:虎杖、厚朴、片姜黄的TLC分离效果好,无阴性干扰;白藜芦醇苷在0.121 2~0.323 2μg范围内呈良好的线性关系r=0.999 9,平均加样回收率=98.10%,RSD%=0.98%.结论:所建立的质量标准可有效地控制肝毒净丸的质量.

针对目前总体经验模式分解(EEMD)方法中两个参数依靠人工选择难以准确获取的问题,提出了一种可自适应确定二者取值的改进EEMD方法.首先通过提取信号中的高频成分来确定加入白噪声的幅值,再根据减小白噪声影响的统计规律得到总体平均次数.同时,为提高分解效率及降低白噪声影响,在EEMD过程中引入有限带宽高斯白噪声消除模态混叠,实现对信号的快速准确分解.信号仿真试验表明改进EEMD方法可以得到比EMD和原始EEMD更加高效的分解结果.最后将其应用于混合信号输入的模拟电路故障特征提取中,以输出响应EEMD分解得到的IMF能量作为特征进行不同故障的分类,仿真结果表明该方法提取的电路各状态特征可作为故障识别和诊断的依据.

银屑病是一种慢性反复发作的炎症性皮肤病,发病机制尚未完全明确,虽然治疗方法较多,但仅能达到近期疗效而无一能完全根治,近年来中医对本病的研究日益深入,不论临床治疗还是实验研究都有很大进展.现就目前中医、中西医结合治疗银屑病的现状结合我们的认识作以下介绍,以期对深化本病的研究有所裨助.1中医对银屑病病因病机的认识银屑病类似中医文献记载的白疕、松皮癣、白壳疮等,银屑病的发病原因较复杂,有外因、内因两种,

目的:探讨白藜芦醇(resveratrol,Res)对视网膜色素上皮细胞增殖的影响,并初步探讨其作用机制.方法:用0、50、100、150、200和300μmol/L Res作用于ARPE-19细胞24、48和72 h后,CCK-8法检测Res对ARPE-19细胞增殖的影响,0、100、150和200μmol/L Res作用ARPE-19细胞48 h,PI单染流式细胞术检测细胞周期,Annexin V-FITC/PI双染流式细胞术检测细胞凋亡,免疫荧光化学法检测PCNA蛋白表达,实时荧光定量PCR(real-time PCR)法检测PCNA、P21和P27的mRNA表达水平.结果:CCK-8结果显示,Res抑制ARPE-19细胞增殖,呈时间和剂量依赖性;流式细胞术显示,Res使S期细胞百分比显著上升且各组凋亡率没有区别;免疫荧光显示,Res抑制PCNA蛋白表达,荧光减弱;real-time PCR显示,Res浓度依赖性地抑制PCNA的mRNA表达,而诱导表达P21和P27的mRNA.结论:Res能抑制ARPE-19细胞的增殖,使细胞阻滞在S期,其机制可能与白藜芦醇诱导P21与P27的mRNA表达、抑制PCNA的mRNA表达有关.